Former first lady Barbara Bush, wife of President George H.W. Bush and mother of President George W. Bush, founded the Barbara Bush Foundation for Family Literacy.

When Hillary Clinton was elected to the U.S. Senate in 2001, she became the first American first lady to ever win a public office seat. She later became the 67th U.S. secretary of state in 2009, serving until 2013. In 2016, she became the first woman in U.S. history to become the presidential nominee of a major political party.

Promoting her cyberbullying campaign, Melania Trump warned of “destructive” and "harmful" social media. "This is why Be Best chooses to focus on the importance of teaching our next generation how to conduct themselves safely and in a positive manner in an online setting," she said.

The wife of President Franklin D. Roosevelt, Eleanor Roosevelt changed the role of the first lady through her active participation in American politics.

Michelle Obama is the wife of former U.S. President Barack Obama. Prior to her role as first lady, she was a lawyer, Chicago city administrator and community-outreach worker.

Betty Ford became the First Lady when President Nixon resigned and made her Vice President husband, Gerald Ford, the acting President.

Abigail Adams was the wife of President John Adams and the mother of John Quincy Adams, who became the sixth president of the United States.

Jacqueline Kennedy Onassis, noted for her style and elegance, was the wife of President John F. Kennedy and a U.S. first lady. After Kennedy's death, she married Greek shipping magnate Aristotle Onassis.

Mary Todd Lincoln was the wife of Abraham Lincoln, the 16th president of the United States.

The wife of U.S. President Lyndon B. Johnson, Lady Bird Johnson served as first lady from 1963 to 1969.

Nancy Reagan was a former Hollywood actress, the first lady of the United States during President Ronald Reagan's time in office and the founder of the "Just Say No" drug awareness campaign.

Former First Lady Laura Bush described a policy splitting up families who illegally cross the U.S.-Mexican border as cruel, immoral and heart breaking in the Washington Post. A spokesperson for Melania Trump said she "hates to see children separated from their families."

Dolley Madison is best known as the wife of United States President James Madison, who served from 1809 to 1817.

Martha Washington was the wife of President George Washington and thus the original first lady of the United States.

Rosalynn Carter is an American First Lady best known as the wife of President Jimmy Carter during his term from 1977-'81.