Henry Sweets grew up in Hannibal, Missouri. He earned a B.S. and Masters in Education from the University of Illinois and a Masters in American History and Museum Studies from the University of Delaware. He has been at the Mark Twain Boyhood Home and Museum in Hannibal, Missouri, since January, 1978. He organized and has overseen the Mark Twain Teacher Workshops for 10 years, and edits The Fence Painter, now in its 36th year. In 2011 and 2015 he ran The Clemens Conference, a quadrennial scholarly Mark Twain conference. Sweets has traveled the United States speaking on Mark Twain.