He was a successful stand up comedian and actor, but after three decades in show business Howie Mandel was thinking of walking away. Now he's the host of one of the hottest shows on TV -- Deal or No Deal. His career was built on frenetic energy and boyish charm, but the silliness belied a serious problem. Howie kept his Obsessive Compulsive Disorder a secret for years -- his fear of germs so profound he's afraid to shake hands. He still struggles with the mental disorder, calling it the biggest barrier in his life -- but it hasn't kept him from having a family, a successful career -- and an endearing sense of humor.