Susan B. Anthony was a prominent American civil rights activist and leader during the women's suffrage movement of the 1800s.
Dorothy Arzner was a pioneer in the film industry, becoming one of the first women directors of feature films and the first woman to join the Directors Guild of America.
One of America's most beloved comedians, Lucille Ball is particularly known for her iconic TV show I Love Lucy.
Sirimavo R.D. Bandaranaike was a Sri Lankan political leader, becoming the world’s first woman prime minister in 1960.
Clara Barton was an educator, nurse and founder of the American Red Cross.
Halle Berry is an American actress, former fashion model and former beauty queen. One of the highest-paid actresses in Hollywood, she is also a Revlon spokeswoman.
Filmmaker Kathryn Bigelow has directed films like Point Break and Zero Dark Thirty. In 2009, she became the first woman to win an Academy Award for best director for The Hurt Locker (2008).
Elizabeth Blackwell was the first woman to graduate from medical school in the United States. She became a leading public health activist during her lifetime.
Gwendolyn Brooks was a postwar poet best known as the first African American to win a Pulitzer Prize, for her 1949 book Annie Allen.
Carol Burnett is a comedian and actress who had a long-running sketch and variety show, The Carol Burnett Show, in the 1960s and '70s.
Rachel Carson was a marine biologist, environmentalist and writer who alerted the world to the environmental impact of fertilizers and pesticides.
Mary Ann Shadd Cary was an active abolitionist and the first female African-American newspaper editor in North America.
With her trademark suits and little black dresses, fashion designer Coco Chanel created timeless designs that are still popular today.
Shirley Chisholm was the first black congresswoman, and the first African-American woman to make a bid for the U.S. Presidency.
When Hillary Clinton was elected to the U.S. Senate in 2001, she became the only American first lady to hold national office. She became the 67th U.S. secretary of state in 2009, serving until 2013.
Jacqueline Cochran is a pioneering 20th century pilot who was an advocate for female aviators during WWII and the first woman to break the sound barrier.
Diane Crump was a professional jockey who racked up more than 230 victories in her career.
Marie Curie was a Polish-born French physicist famous for her work on radioactivity and twice a winner of the Nobel Prize.
Dorothy Dandridge was an American actress and popular singer, and was the first African American to be nominated for an Academy Award for best actress.
Olympic gymnast Gabby Douglas is best known as the first African American to win the individual all-around event. She also won a team gold medal for the U.S. at the 2012 Summer Olympics.
Amelia Earhart, the first female pilot to fly across the Atlantic Ocean, mysteriously disappeared while flying over the Pacific Ocean in 1937.
American swimmer Gertrude Ederle achieved fame when she competed in the 1924 Olympics and became the first woman to swim across the English Channel in 1926.
American biochemist and pharmacologist Gertrude B. Elion helped develop drugs to treat leukemia and prevent kidney transplant rejection. She won a Nobel Prize for medicine in 1988.
Geraldine A. Ferraro was a member of Congress and the first woman to run for the U.S. vice presidency on a major party platform.
Martha Gellhorn was a distinguished war correspondent who covered every war that occurred across the globe over a period extending nearly 60 years.
Bernice Gera became the first female umpire of a baseball game in 1972, but later resigned, reportedly because other umpires refused to work with her.
Ruth Bader Ginsburg is a U.S. Supreme Court Justice, the second woman to be appointed to the position.
Janet Guthrie was the first female racecar driver to compete in a NASCAR Winston Cup stock car race, the Indianapolis 500 and Daytona 500.
Playwright and activist Lorraine Hansberry wrote A Raisin in the Sun and was the first black playwright and the youngest American to win a New York Critics’ Circle award.
20th century recording artist Mahalia Jackson, known as the Queen of Gospel, is revered as one of the greatest musical figures in U.S. history.
Doctor Mae C. Jemison is the first African-American woman ever to be a U.S. astronaut. In 1992, she flew into space aboard the Endeavour.
Mary Lyon was an educator and founder of the first women's college, which is now known as Mount Holyoke College.
Wangari Maathai was a Kenyan political and environmental activist and her country's assistant minister of environment, natural resources and wildlife.
Pop legend Madonna is known for her constant reinvention as a performer. Her biggest hits include "Papa Don't Preach," "Like a Prayer" and "Vogue."
High school teacher Christa McAuliffe was the first American civilian selected to go into space. She died in the space shuttle Challenger’s explosion in 1986.
Singer-songwriter Joni Mitchell, responsible for hits such as "Both Sides Now" and "Big Yellow Taxi," is widely considered 1960s and '70s folk royalty.
Toni Morrison is a Nobel Prize- and Pulitzer Prize-winning American novelist. Among her best known novels are The Bluest Eye, Song of Solomon and Beloved.
Constance Baker Motley was a legal advocate in the Civil Rights Movement. She became the first female African-American federal judge in 1966.
Shirley Muldowney is recognized as one of the top professional car racers in the world, having earned the moniker "First Lady of Drag Racing."
Florence Nightingale, a nurse, spent her night rounds giving personal care to the wounded, establishing her image as the 'Lady with the Lamp.'
Antonia C. Novello is a former U.S. surgeon general who was the first woman and first person of Latin descent to hold the position.
Sandra Day O'Connor was the first woman appointed to the U.S. Supreme Court. A Republican, she was considered a moderate conservative and served for 24 years.
Annie Oakley was a renowned markswoman and star who worked for years with Buffalo Bill's Wild West Show.
Danica Patrick is a female race car driver and has set several records for women drivers, including becoming the first woman to lead the Indy 500 and the first woman to win the pole position at the Daytona 500.
Annie Smith Peck was a trailblazing scholar, writer and athlete who set records as a mountain climber in the late 19th and early 20th centuries.
Frances Perkins was the first female to serve in the U.S. presidential cabinet. As secretary of labor, she helped with the New Deal and Social Security.
Pocahontas, later known as Rebecca Rolfe, was a Native American who assisted English colonists during their first years in Virginia.
Florence Beatrice Price was an award-winning pianist and composer who became the first African-American woman to have her work performed by a major symphony.
Jeannette Rankin was the first woman to serve in the U.S. Congress. She helped pass the 19th Amendment, giving women the right to vote, and was a committed pacifist.
Mary Lou Retton is a retired champion gymnast who won gold, silver and bronze medals at the 1984 Olympics. She was featured on the Wheaties cereal box.
Condoleezza Rice is the first black woman to serve as the United States' national security adviser, as well as the first black woman to serve as U.S. Secretary of State (2005-09).
In 1983, astronaut and astrophysicist Sally Ride became the first American woman in space aboard the space shuttle Challenger. Ride died on July 23, 2012 at the age of 61, following a battle with pancreatic cancer.
Nominated by President Barack Obama on May 26, 2009, Sonia Sotomayor became the first Latina Supreme Court Justice in US history.
Award-winning actress Meryl Streep is a star of stage and screen, known for her work in such diverse films as The Deer Hunter, Adaptation, Mamma Mia! and Doubt.
Jessie Tarbox was a photographer and photojournalist. She was the first woman to be hired as a staff photographer on a U.S. newspaper.
The first female prime minister of Britain, Margaret Thatcher was a controversial figurehead of conservative ideology during her time in office.
Debi Thomas was a figure skater who went on to become the first African-American to win an Olympic medal at the Winter Olympics.
Madam C.J. Walker was the first American woman to become a self-made millionaire. Her business was worth more than $1 million at the time of her death.
A country music legend, Kitty Wells had a string of hits in the 1950s and '60s, including "It Wasn't God Who Made Honky Tonk Angels."
Mary Wollstonecraft was an English writer who advocated for women's equality. Her book A Vindication of the Rights of Woman pressed for educational reforms.
Victoria Woodhull was a spiritualist, activist, politician and author who was the first woman to run for the presidency of the United States.